AustralieFrV1, Main, Exploration, bibRecord, 000471

Reduced intensity conditioned allograft yields favorable survival for older adults with B-cell acute lymphoblastic leukemia.

Identifieur interne : 000471 ( Main/Exploration ); précédent : 000470; suivant : 000472

Reduced intensity conditioned allograft yields favorable survival for older adults with B-cell acute lymphoblastic leukemia.

Auteurs : Ashley Rosko [États-Unis] ; Hai-Lin Wang [États-Unis] ; Marcos De Lima [États-Unis] ; Brenda Sandmaier [États-Unis] ; H Jean Khoury [États-Unis] ; Andrew Artz [États-Unis] ; Johnathan Brammer [États-Unis] ; Christopher Bredeson [Canada] ; Sherif Farag [États-Unis] ; Mohamed Kharfan-Dabaja [États-Unis] ; Hillard M. Lazarus [États-Unis] ; David I. Marks [Royaume-Uni] ; Rodrigo Martino Bufarull [Espagne] ; Joseph Mcguirk [États-Unis] ; Mohamed Mohty [France] ; Taiga Nishihori [États-Unis] ; Ian Nivison-Smith [Australie] ; Armin Rashidi [États-Unis] ; Olle Ringden [Suède] ; Matthew Seftel [Canada] ; Daniel Weisdorf [États-Unis] ; Veronika Bachanova [États-Unis] ; Wael Saber [États-Unis]

Source :

American journal of hematology [ 1096-8652 ] ; 2017.

RBID : pubmed:27712033

Descripteurs français

English descriptors

KwdEn :
- Aged, Disease-Free Survival, Female, Hematopoietic Stem Cell Transplantation (methods), Humans, Kaplan-Meier Estimate, Male, Middle Aged, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (epidemiology), Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (therapy), Proportional Hazards Models, Recurrence, Retrospective Studies, Transplantation Conditioning (methods).
MESH :
- epidemiology : Precursor B-Cell Lymphoblastic Leukemia-Lymphoma.
- methods : Hematopoietic Stem Cell Transplantation, Transplantation Conditioning.
- therapy : Precursor B-Cell Lymphoblastic Leukemia-Lymphoma.
- Aged, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Proportional Hazards Models, Recurrence, Retrospective Studies.

Abstract

Older adults with B-cell acute lymphoblastic leukemia (B-ALL) have poor survival. We examined the effectiveness of reduced intensity conditioning (RIC) hematopoietic cell transplant (HCT) in adults with B-ALL age 55 years and older and explored prognostic factors associated with long-term outcomes. Using CIBMTR registry data, we evaluated 273 patients (median age 61, range 55-72) with B-ALL with disease status in CR1 (71%), >CR2 (17%) and Primary Induction Failure (PIF)/Relapse (11%), who underwent RIC HCT between 2001 and 2012 using mostly unrelated donor (59%) or HLA-matched sibling (32%). Among patients with available cytogenetic data, the Philadelphia chromosome (Ph+) was present in 50%. The 3-year cumulative incidences of nonrelapse mortality (NRM) and relapse were 25% (95% confidence intervals (CI): 20-31%) and 47% (95% CI: 41-53%), respectively. Three-year overall survival (OS) was 38% (95% CI: 33-44%). Relapse remained the leading cause of death accounting for 49% of all deaths. In univariate analysis, 3 year risk of NRM was significantly higher with reduced Karnofsky performance status (KPS <90: 34% (95% CI: 25-43%) versus KPS ≥90 (18%; 95% CI: 12-24%, P = 0.006). Mortality was increased in older adults (66+ vs. 55-60: Relative Risk [RR] 1.51 95% CI: 1.00-2.29, P = 0.05) and those with advanced disease (RR 2.13; 95% CI: 1.36-3.34, P = 0.001). Survival of patients in CR1 yields 45% (95% CI: 38-52%) at 3 years and no relapse occurred after 2 years. We report promising OS and acceptable NRM using RIC HCT in older patients with B-ALL. Disease status in CR1 and good performance status are associated with improved outcomes. Am. J. Hematol. 92:42-49, 2017. © 2016 Wiley Periodicals, Inc.

DOI: 10.1002/ajh.24575
PubMed: 27712033

Affiliations:

Australie, Canada, Espagne, France, Royaume-Uni, Suède, États-Unis
Catalogne, Floride, Géorgie (États-Unis), Illinois, Indiana, Kansas, Minnesota, Missouri (État), Ohio, Svealand, Texas, Washington (État), Wisconsin, Île-de-France
Barcelone, Paris, Stockholm

Le document en format XML

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<author><name sortKey="Farag, Sherif" sort="Farag, Sherif" uniqKey="Farag S" first="Sherif" last="Farag">Sherif Farag</name>
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<author><name sortKey="Kharfan Dabaja, Mohamed" sort="Kharfan Dabaja, Mohamed" uniqKey="Kharfan Dabaja M" first="Mohamed" last="Kharfan-Dabaja">Mohamed Kharfan-Dabaja</name>
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</affiliation>
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<author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M" last="Lazarus">Hillard M. Lazarus</name>
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<author><name sortKey="Mcguirk, Joseph" sort="Mcguirk, Joseph" uniqKey="Mcguirk J" first="Joseph" last="Mcguirk">Joseph Mcguirk</name>
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<author><name sortKey="Mohty, Mohamed" sort="Mohty, Mohamed" uniqKey="Mohty M" first="Mohamed" last="Mohty">Mohamed Mohty</name>
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<author><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name>
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<placeName><region type="state">Floride</region>
</placeName>
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</affiliation>
</author>
<author><name sortKey="Nivison Smith, Ian" sort="Nivison Smith, Ian" uniqKey="Nivison Smith I" first="Ian" last="Nivison-Smith">Ian Nivison-Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>St. Vincent's Hospital, Darlinghurst, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>St. Vincent's Hospital, Darlinghurst, NSW</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Rashidi, Armin" sort="Rashidi, Armin" uniqKey="Rashidi A" first="Armin" last="Rashidi">Armin Rashidi</name>
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</placeName>
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<author><name sortKey="Ringden, Olle" sort="Ringden, Olle" uniqKey="Ringden O" first="Olle" last="Ringden">Olle Ringden</name>
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</placeName>
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<author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name>
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<author><name sortKey="Weisdorf, Daniel" sort="Weisdorf, Daniel" uniqKey="Weisdorf D" first="Daniel" last="Weisdorf">Daniel Weisdorf</name>
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</placeName>
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</affiliation>
</author>
<author><name sortKey="Bachanova, Veronika" sort="Bachanova, Veronika" uniqKey="Bachanova V" first="Veronika" last="Bachanova">Veronika Bachanova</name>
<affiliation wicri:level="2"><nlm:affiliation>Bone and Marrow Transplant Program, University of Minnesota Medical Center, Minneapolis, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Bone and Marrow Transplant Program, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>CIBMTR (Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Reduced intensity conditioned allograft yields favorable survival for older adults with B-cell acute lymphoblastic leukemia.</title>
<author><name sortKey="Rosko, Ashley" sort="Rosko, Ashley" uniqKey="Rosko A" first="Ashley" last="Rosko">Ashley Rosko</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
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<wicri:cityArea>James Cancer Center, Ohio State University, Columbus</wicri:cityArea>
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<author><name sortKey="Wang, Hai Lin" sort="Wang, Hai Lin" uniqKey="Wang H" first="Hai-Lin" last="Wang">Hai-Lin Wang</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
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</affiliation>
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<author><name sortKey="De Lima, Marcos" sort="De Lima, Marcos" uniqKey="De Lima M" first="Marcos" last="De Lima">Marcos De Lima</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Department of Medicine, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sandmaier, Brenda" sort="Sandmaier, Brenda" uniqKey="Sandmaier B" first="Brenda" last="Sandmaier">Brenda Sandmaier</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Division of Medical Oncology, University of Washington and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Khoury, H Jean" sort="Khoury, H Jean" uniqKey="Khoury H" first="H Jean" last="Khoury">H Jean Khoury</name>
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</placeName>
<wicri:cityArea>Emory University Hospital, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Artz, Andrew" sort="Artz, Andrew" uniqKey="Artz A" first="Andrew" last="Artz">Andrew Artz</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Section of Hematology/Oncology, University of Chicago School of Medicine, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Brammer, Johnathan" sort="Brammer, Johnathan" uniqKey="Brammer J" first="Johnathan" last="Brammer">Johnathan Brammer</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>M.D. Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bredeson, Christopher" sort="Bredeson, Christopher" uniqKey="Bredeson C" first="Christopher" last="Bredeson">Christopher Bredeson</name>
<affiliation wicri:level="1"><nlm:affiliation>The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Farag, Sherif" sort="Farag, Sherif" uniqKey="Farag S" first="Sherif" last="Farag">Sherif Farag</name>
<affiliation wicri:level="2"><nlm:affiliation>Indiana University Hospital/ Riley Hospital for Children, Indianapolis, IN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Indiana</region>
</placeName>
<wicri:cityArea>Indiana University Hospital/ Riley Hospital for Children, Indianapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kharfan Dabaja, Mohamed" sort="Kharfan Dabaja, Mohamed" uniqKey="Kharfan Dabaja M" first="Mohamed" last="Kharfan-Dabaja">Mohamed Kharfan-Dabaja</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Blood and Marrow Transplantation, H. Lee Moffit Cancer Center and Research Institute, Tampa, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Blood and Marrow Transplantation, H. Lee Moffit Cancer Center and Research Institute, Tampa</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M" last="Lazarus">Hillard M. Lazarus</name>
<affiliation wicri:level="2"><nlm:affiliation>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name>
<affiliation wicri:level="1"><nlm:affiliation>Adult Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Adult Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bufarull, Rodrigo Martino" sort="Bufarull, Rodrigo Martino" uniqKey="Bufarull R" first="Rodrigo Martino" last="Bufarull">Rodrigo Martino Bufarull</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Hematology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
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<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
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<author><name sortKey="Mcguirk, Joseph" sort="Mcguirk, Joseph" uniqKey="Mcguirk J" first="Joseph" last="Mcguirk">Joseph Mcguirk</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Kansas, Westwood, KS.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea>University of Kansas, Westwood</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mohty, Mohamed" sort="Mohty, Mohamed" uniqKey="Mohty M" first="Mohamed" last="Mohty">Mohamed Mohty</name>
<affiliation wicri:level="3"><nlm:affiliation>Hopital Saint-Antoine, APHP, Universite Pierre & Marie Curie, INSERM UMRs U938, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hopital Saint-Antoine, APHP, Universite Pierre & Marie Curie, INSERM UMRs U938, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Blood and Marrow Transplantation, H. Lee Moffit Cancer Center and Research Institute, Tampa, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Blood and Marrow Transplantation, H. Lee Moffit Cancer Center and Research Institute, Tampa</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nivison Smith, Ian" sort="Nivison Smith, Ian" uniqKey="Nivison Smith I" first="Ian" last="Nivison-Smith">Ian Nivison-Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>St. Vincent's Hospital, Darlinghurst, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>St. Vincent's Hospital, Darlinghurst, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
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<author><name sortKey="Rashidi, Armin" sort="Rashidi, Armin" uniqKey="Rashidi A" first="Armin" last="Rashidi">Armin Rashidi</name>
<affiliation wicri:level="2"><nlm:affiliation>Barnes Jewish Hospital, St. Louis, MO.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
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<wicri:cityArea>Barnes Jewish Hospital, St. Louis</wicri:cityArea>
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<author><name sortKey="Ringden, Olle" sort="Ringden, Olle" uniqKey="Ringden O" first="Olle" last="Ringden">Olle Ringden</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
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<author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
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</author>
<author><name sortKey="Weisdorf, Daniel" sort="Weisdorf, Daniel" uniqKey="Weisdorf D" first="Daniel" last="Weisdorf">Daniel Weisdorf</name>
<affiliation wicri:level="2"><nlm:affiliation>Divsion of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Divsion of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bachanova, Veronika" sort="Bachanova, Veronika" uniqKey="Bachanova V" first="Veronika" last="Bachanova">Veronika Bachanova</name>
<affiliation wicri:level="2"><nlm:affiliation>Bone and Marrow Transplant Program, University of Minnesota Medical Center, Minneapolis, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Bone and Marrow Transplant Program, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<affiliation wicri:level="2"><nlm:affiliation>CIBMTR (Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>CIBMTR (Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
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</author>
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<series><title level="j">American journal of hematology</title>
<idno type="eISSN">1096-8652</idno>
<imprint><date when="2017" type="published">2017</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Hematopoietic Stem Cell Transplantation (methods)</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (epidemiology)</term>
<term>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (therapy)</term>
<term>Proportional Hazards Models</term>
<term>Recurrence</term>
<term>Retrospective Studies</term>
<term>Transplantation Conditioning (methods)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Conditionnement pour greffe ()</term>
<term>Estimation de Kaplan-Meier</term>
<term>Femelle</term>
<term>Humains</term>
<term>Leucémie-lymphome lymphoblastique à précurseurs B ()</term>
<term>Leucémie-lymphome lymphoblastique à précurseurs B (épidémiologie)</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Récidive</term>
<term>Sujet âgé</term>
<term>Survie sans rechute</term>
<term>Transplantation de cellules souches hématopoïétiques ()</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Hematopoietic Stem Cell Transplantation</term>
<term>Transplantation Conditioning</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Leucémie-lymphome lymphoblastique à précurseurs B</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Proportional Hazards Models</term>
<term>Recurrence</term>
<term>Retrospective Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Conditionnement pour greffe</term>
<term>Estimation de Kaplan-Meier</term>
<term>Femelle</term>
<term>Humains</term>
<term>Leucémie-lymphome lymphoblastique à précurseurs B</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Récidive</term>
<term>Sujet âgé</term>
<term>Survie sans rechute</term>
<term>Transplantation de cellules souches hématopoïétiques</term>
<term>Études rétrospectives</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Older adults with B-cell acute lymphoblastic leukemia (B-ALL) have poor survival. We examined the effectiveness of reduced intensity conditioning (RIC) hematopoietic cell transplant (HCT) in adults with B-ALL age 55 years and older and explored prognostic factors associated with long-term outcomes. Using CIBMTR registry data, we evaluated 273 patients (median age 61, range 55-72) with B-ALL with disease status in CR1 (71%), >CR2 (17%) and Primary Induction Failure (PIF)/Relapse (11%), who underwent RIC HCT between 2001 and 2012 using mostly unrelated donor (59%) or HLA-matched sibling (32%). Among patients with available cytogenetic data, the Philadelphia chromosome (Ph+) was present in 50%. The 3-year cumulative incidences of nonrelapse mortality (NRM) and relapse were 25% (95% confidence intervals (CI): 20-31%) and 47% (95% CI: 41-53%), respectively. Three-year overall survival (OS) was 38% (95% CI: 33-44%). Relapse remained the leading cause of death accounting for 49% of all deaths. In univariate analysis, 3 year risk of NRM was significantly higher with reduced Karnofsky performance status (KPS <90: 34% (95% CI: 25-43%) versus KPS ≥90 (18%; 95% CI: 12-24%, P = 0.006). Mortality was increased in older adults (66+ vs. 55-60: Relative Risk [RR] 1.51 95% CI: 1.00-2.29, P = 0.05) and those with advanced disease (RR 2.13; 95% CI: 1.36-3.34, P = 0.001). Survival of patients in CR1 yields 45% (95% CI: 38-52%) at 3 years and no relapse occurred after 2 years. We report promising OS and acceptable NRM using RIC HCT in older patients with B-ALL. Disease status in CR1 and good performance status are associated with improved outcomes. Am. J. Hematol. 92:42-49, 2017. © 2016 Wiley Periodicals, Inc.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Catalogne</li>
<li>Floride</li>
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<li>Illinois</li>
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<li>Minnesota</li>
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<li>Wisconsin</li>
<li>Île-de-France</li>
</region>
<settlement><li>Barcelone</li>
<li>Paris</li>
<li>Stockholm</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Ohio"><name sortKey="Rosko, Ashley" sort="Rosko, Ashley" uniqKey="Rosko A" first="Ashley" last="Rosko">Ashley Rosko</name>
</region>
<name sortKey="Artz, Andrew" sort="Artz, Andrew" uniqKey="Artz A" first="Andrew" last="Artz">Andrew Artz</name>
<name sortKey="Bachanova, Veronika" sort="Bachanova, Veronika" uniqKey="Bachanova V" first="Veronika" last="Bachanova">Veronika Bachanova</name>
<name sortKey="Brammer, Johnathan" sort="Brammer, Johnathan" uniqKey="Brammer J" first="Johnathan" last="Brammer">Johnathan Brammer</name>
<name sortKey="De Lima, Marcos" sort="De Lima, Marcos" uniqKey="De Lima M" first="Marcos" last="De Lima">Marcos De Lima</name>
<name sortKey="Farag, Sherif" sort="Farag, Sherif" uniqKey="Farag S" first="Sherif" last="Farag">Sherif Farag</name>
<name sortKey="Kharfan Dabaja, Mohamed" sort="Kharfan Dabaja, Mohamed" uniqKey="Kharfan Dabaja M" first="Mohamed" last="Kharfan-Dabaja">Mohamed Kharfan-Dabaja</name>
<name sortKey="Khoury, H Jean" sort="Khoury, H Jean" uniqKey="Khoury H" first="H Jean" last="Khoury">H Jean Khoury</name>
<name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M" last="Lazarus">Hillard M. Lazarus</name>
<name sortKey="Mcguirk, Joseph" sort="Mcguirk, Joseph" uniqKey="Mcguirk J" first="Joseph" last="Mcguirk">Joseph Mcguirk</name>
<name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name>
<name sortKey="Rashidi, Armin" sort="Rashidi, Armin" uniqKey="Rashidi A" first="Armin" last="Rashidi">Armin Rashidi</name>
<name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<name sortKey="Sandmaier, Brenda" sort="Sandmaier, Brenda" uniqKey="Sandmaier B" first="Brenda" last="Sandmaier">Brenda Sandmaier</name>
<name sortKey="Wang, Hai Lin" sort="Wang, Hai Lin" uniqKey="Wang H" first="Hai-Lin" last="Wang">Hai-Lin Wang</name>
<name sortKey="Weisdorf, Daniel" sort="Weisdorf, Daniel" uniqKey="Weisdorf D" first="Daniel" last="Weisdorf">Daniel Weisdorf</name>
</country>
<country name="Canada"><noRegion><name sortKey="Bredeson, Christopher" sort="Bredeson, Christopher" uniqKey="Bredeson C" first="Christopher" last="Bredeson">Christopher Bredeson</name>
</noRegion>
<name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name>
</noRegion>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Bufarull, Rodrigo Martino" sort="Bufarull, Rodrigo Martino" uniqKey="Bufarull R" first="Rodrigo Martino" last="Bufarull">Rodrigo Martino Bufarull</name>
</region>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Mohty, Mohamed" sort="Mohty, Mohamed" uniqKey="Mohty M" first="Mohamed" last="Mohty">Mohamed Mohty</name>
</region>
</country>
<country name="Australie"><noRegion><name sortKey="Nivison Smith, Ian" sort="Nivison Smith, Ian" uniqKey="Nivison Smith I" first="Ian" last="Nivison-Smith">Ian Nivison-Smith</name>
</noRegion>
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<country name="Suède"><region name="Svealand"><name sortKey="Ringden, Olle" sort="Ringden, Olle" uniqKey="Ringden O" first="Olle" last="Ringden">Olle Ringden</name>
</region>
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</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Reduced intensity conditioned allograft yields favorable survival for older adults with B-cell acute lymphoblastic leukemia.

Reduced intensity conditioned allograft yields favorable survival for older adults with B-cell acute lymphoblastic leukemia.

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